Blastopathies and microcephaly in a Chornobyl impacted region of Ukraine
نویسندگان
چکیده
This population-based descriptive epidemiology study demonstrates that rates of conjoined twins, teratomas, neural tube defects, microcephaly, and microphthalmia in the Rivne province of Ukraine are among the highest in Europe. The province is 200 km distant from the Chornobyl site and its northern half, a region known as Polissia, is significantly polluted by ionizing radiation. The rates of neural tube defects, microcephaly and microphthalmia in Polissia are statistically significantly higher than in the rest of the province. A survey of at-birth head size showed that values were statistically smaller in males and females born in one Polissia county than among neonates born in the capital city. These observations provide clues for confirmatory and cause-effect prospective investigations. The strength of this study stems from a reliance on international standards prevalent in Europe and a decade-long population-based surveillance of congenital malformations in two distinct large populations. The limitations of this study, as those of other descriptive epidemiology investigations, is that identified cause-effect associations require further assessment by specific prospective investigations designed to address specific teratogenic factors.
منابع مشابه
Pregnant Women with High Levels of Caesium and High Rates of Congenital Anomalies near Chornobyl
We report population-based rates of congenital anomalies in the Rivne province of Ukraine. The rates are significantly higher in the northern half of Rivne, a region called Polissia which is polluted by Chornobyl ionizing radiation. In this region of forested wet-lands, also called Prypiat Marshlands, the soils are distinct from those in non-Polissia. The soils in Polissia transfer caesium more...
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OBJECTIVE One of the populations most exposed to chronic low-dose radiation from Chornobyl (Chernobyl in Russian) lives in Polissia, the region representing the northern half of Rivne Province (Oblast) in Ukraine. Here the patterns and population rates of malformations are reported and possible etiologic factors and regional contrasts are explored. PATIENTS AND METHODS Malformations, as defin...
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At radioactive sites, at least two mechanisms may affect the genetic diversity of populations of a given species. Increased mutation rates due to radiation exposure may increase the amount of genetic diversity in a population. Alternatively, population bottlenecks exacerbated by environmental degradation may lead to a reduction of diversity. The relationship between these two contradictory forc...
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